Effects Of F-18 On KCL And Phenylephrine - Induced Contractions Of Rat Aorta
Abdisalim A. ZaripovKarakalpak State University Named After Berdakh, Nukus, UzbekistanAdilbay T. EsimbetovDurdona Shokirova Institute Of Biophysics And Biochemistry, National University Of Uzbekistan, Tashkent, UzbekistanPulat B. UsmanovKarakalpak State University Named After Berdakh, Nukus, UzbekistanDurdona ShokirovaSherzod ZhurakulovDurdona Shokirova Institute Of Biophysics And Biochemistry, National University Of Uzbekistan, Tashkent, Uzbekistan
ABI
Аннотация
The mechanism of action of the alkaloid 1-(2´-bromine-4´,5´-dimethoxyphenyl) - 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) on the functional activity of smooth muscle cells of the rat aorta was studied. Isometric contraction activity was recorded using a Grass FT – 03 (Grass Instrument, USA) mechanotron. The relaxant effect of the F-18 alkaloid was found to be associated with blockade of Ca2 + (IP3R) channels in the SR, along with voltage- dependent and receptor-operated Ca2+channels in the aorta smooth muscle cell plasmalemma.
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