The relationship between vitamin D levels and obesity in patients with overlapping bronchial asthma and COPD.

Vitamin D, also known as the sunshine vitamin, was first identified in the early 20th century and is linked to research on rickets. Its participation in the formation of local immunity of the respiratory tract has been proven. Vitamin D in obesity has direct and indirect mechanisms of influence. BMI is not only a diagnostic criterion for obesity, but also an indicator of the relative risk of developing diseases associated with obesity, in particular BA and COPD. Since asthma-COPD overlap syndrome (ACO) is a controversial and multifaceted pathological process, the study of vitamin D concentration as one of the factors leading to the development of a vicious circle is relevant. Objective: to assess the level of vitamin D (25-hydroxyvitamin D [25 (OH) D]) in patients with BA / COPD, ACO and its correlation with anthropometric and clinical parameters. Materials and Methods: The study involved 159 men and women (asthma, n = 62; COPD, n = 67; and ACO, n = 30) from 2020 to 2021. All patients underwent clinical, instrumental and immunological examination. Research results: Our data show that all obese and overweight patients have a deficiency of vitamin D content and its lowest level is observed in patients with asthma and COPD intersection. Conclusions: Thus, the above data indicate the need to prescribe vitamin D for patients with AD, COPD and ACO for a long time. Our data show that all obese and overweight patients have a deficiency of vitamin D content and its lowest level is observed in patients with asthma and COPD intersection. Conclusions: Thus, the above data indicate the need to prescribe vitamin D for patients with AD, COPD and ACO for a long time. Our data show that all obese and overweight patients have a deficiency of vitamin D content and its lowest level is observed in patients with asthma and COPD intersection. Conclusions: Thus, the above data indicate the need to prescribe vitamin D for patients with AD, COPD and ACO for a long time.

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