ROLE OF GENETIC MARKERS OF DISORDER PLATE LINE OF HEMOSTASIS (ITGB3 and ITGA2) IN PATHOGENESIS ISCHEMIC STROKE
Musashaikhov Umidzhon KhusanovichAndijan State Medical InstituteMusashaikhova Shakhnoza MamirbekovnaAndijan State Medical InstituteKarimov Hamid YakubovichRepublican Specialized Scientific and Practical Medical Center of Hematology of the Ministry of Health of the Republic of UzbekistanBoboev Kodirjon TukhtabaevichRepublican Specialized Scientific and Practical Medical Center of Hematology of the Ministry of Health of the Republic of Uzbekistan
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In the course of the study, in 35 patients with ischemic stroke, the associative relationship of the Leu33Pro polymorphism in the integrin beta-3 gene (ITGB3) and the polymorphic marker C807T in the integrin alpha-2 gene (ITGA2) in the formation of IS was analyzed. A study was conducted in patients with IS, a significant relationship was established between the risk of developing this pathology and the distribution of predisposing / protective variants of the ITGB3 and ITGA2 polymorphism genotypes. in the gene for the integrin beta 3 (ITGB3) gene C807T and integrin alpha 2 (ITGA2) match expected at equilibrium the HardyWeinberg equilibrium (HWE) (p <0.05).
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