COMPARATIVE ANALYSIS OF THE FREQUENCY OF RS1801133 POLYMORPHISM OF THE MTHFR GENE IN THE GROUP OF PATIENTS WITH POSTCOVID COMPLICATIONS OF MAXILLOFACIAL AREA

In the article of genetic studies of patients with post-covid maxillofacial complications. The condition after COVID-19 is considered a life-threatening disease, ranging from mild symptoms to serious complications. Candidiasis is the most common type of superficial purulent infection. The Candida species is a frequent inhabitant of the oral mucosa, but its growth is inhibited by other organisms in the body, which prevents any pathological change in the mucous membrane of this fungus. Candida albicans is the most common yeast, followed by Candida glabrata, Candida krusei, Candida tropicalis and Candida stellatoidea. According to this systematic review, 57 cases of oral candidiasis and one case of retinitis candidiasis were reported in patients undergoing treatment for COVID-19. Single-cell RNA-seq analysis of angiotensin-converting enzyme II (ACE2) expression and serologic examination of samples indicates that ACE2 may be the cellular receptor for SARS-CoV-2, suggesting that ACE2-expressing cells are likely to be the main target cell type that vulnerable to SARS-CoV-2 infection. As a rule, there is a high expression of ACE2 r on the epithelial cells of the oral mucosa, enrichment is enriched in epithelial cells of the tongue. There were few reports prior to this study.

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