New method for endoscopic hemostasis: application of biopolymers on the gastric ulcer bleeding

Purpose: To substantiate the effectiveness of using domestic production a powdered polymeric hemostaticagent with silver nanoparticles to control bleeding and prevent recurrence of bleeding from experimentalgastric ulcers in dogs.Methods: In vivo experiments were carried out on the basis of the experimental laboratory of the RRCEM.The object of the study was a dog (male, weighing 10 kg). EGD was performed under intravenous anesthesiausing an Olympus GIF-E3 with an adapted video system. A biodegradable biopolymer with silver nanoparticleswas used as a hemostatic agent. Biopsy specimens of the mucous membrane from the edges and bottom ofthe gastric ulcer at each endoscopy served as the material for the morphological study.Results: On the 4th day from the beginning of the experiment, an acute gastric ulcer was obtained. Theobtained visual and morphological data show that the use of biopolymer powder with silver nanoparticlesis effective in the treatment of experimental gastric ulcers, acceleration of the phase change of theulcerative process is noted. The appearance of fibroblasts in the granulation tissue of the ulcer in theabsence of their active reaction from the 4th day of treatment indicated an early onset of the healingprocess, which ended with a delicate scar (the stage of red scar).

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