Correlation of Doppler examination parameters and brain-derived neurotrophic factor, as a neuromarker, in diabetic patients with polyneuropathy at the stage of late complications

The work was initiated to study correlation between ultrasonic Doppler examination parameters and BDNF, a neuro-marker, in blood of patients with type 2 diabetes mellitus (type 2 DM) and diabetic polyneuropathy (DPN) at the stage of late complications. A comparative prospective study with the participation of 215 patients with type 2 DM, 160 subjects with diabetic polyneuropathy at the stage of late complications were conducted from 2018 to 2021. There is a significant correlation between blood BDNF concentrations and laboratory –instrumental parameters. The correlation between the glycated hemoglobin and Doppler examination in both groups of patients was found, while the correlation with the fasting glycaemia was found insignificant. All the findings can be regarded as the evidence for necessity of timely adequate conservative therapy of chronic wound defects in low extremities of patients with type 2 diabetes mellitus as well as for prevention of recurrences and arrangement of long-term follow-up of patients at high risk of diabetic complications.

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