FORMATION OF MESENTERIC LYMPH NODES IN THE DYNAMICS OF EARLY POSTNATAL ONTOGENESIS WITH CHRONIC EXPOSURE TO PESTICIDES THROUGH THE MOTHER'S BODY

Purpose: to study the features of the postnatal development of the lymph nodes of the offspring of females exposed to chronic intoxication with fipronil.\n\nMaterials and methods: mesenteric lymph nodes 3, 7, 14, 21 and 30-day-old rats born from females with chronic intoxication with fipronil and from control rats subjected to morphological, morphometric, and electron microscopic methods of research served as the material for the study.\n\nResults: In experimental rat pups obtained from females under conditions of chronic intoxication with fipronil, there was a significant lag in the formation of structural-functional T- and B-dependent zones of mesenteric lymph nodes, which was carried out 7-9 days later than rat pups with the natural course of postnatal ontogenesis.\n\nConclusions: Chronic exposure to fipronil through the mother's body contributes to a significant disruption of the processes of postnatal growth and the formation of mesenteric lymph nodes in their offspring, which manifest themselves as a slowdown in the growth and formation of the lymphoid tissue of the organ and its structural and functional zones.

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