FUNCTIONAL FEATURES OF PHENOTYPIC MANIFESTATIONS OF OSTEOAR-THRITIS

<strong>Abstract</strong> Introduction. Osteoarthritis is a joint disease characterized by cellular stress and degradation of the extracellular matrix, developing with macro- and micro-damage, which activate an abnormal adaptive repair response, including pro-inflammatory immune mechanisms. Objective. To study the features of the functional state of patients with osteoarthritis by phenotypic signs. Materials and methods: 80 patients diagnosed with osteoarthritis who are on inpatient treatment for the period from January to April 2022 in the State Institution "RSSPMCTandMR" were examined. Verification of the diagnosis according to ACR diagnostic criteria. The distribution of patients by phenotypes was based on classification criteria. Results and discussion. According to the results of the study, there was a significant increase in the indicators of fibrinogen and C-reactive protein in all groups, with the exception of patients with a biomechanical phenotype. These changes reflect a close positive relationship (r=0.252, p0.05) between the systems of inflammation and coagulation processes. According to the results of the study, a comparative analysis of the algofunctional Leken index shows the highest value in patients with the CP phenotype, which is explained by the consequence of the altered phenotype of chondrocytes mediated by various autocrine and paracrine signals, which leads to the synthesis of many inflammatory mediators and degradation. Conclusions: Morphological features of both acute and chronic inflammation are observed and are characterized by recurrent episodes of inflammation. At a late stage, fibrosis may dominate, which is confirmed by an increase in the amount of fibrinogen.

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