The biomedical potential of polycaprolactone nanofibrous scaffold containing titanium oxide for wound healing applications

Wound dressing is one of the most well-known and challenging issues all over the world. Recently, in the field of biological applications, polymeric scaffolds incorporating metal oxide nanoparticles has been extremely important, especially in focusing on wound healing. In this project, we have successfully fabricated a nano-fibrous scaffold using the electrospinning method prepared by poly(ε-caprolactone) (PCL) polymer. Titanium dioxide (TiO2) is incorporated into the PCL solution as a strong antibacterial element and as a tensile strength enhancer. The characterisation of scaffolds was done by transmission electron microscopy (TEM), scanning electron microscopy (SEM), mechanical analysis, and water vapour transmission rate (WVTR), porosity. The nanofibers' biocompatibility and capacity for cell attachment were demonstrated by MTT and 4′,6-diamidino-2-phenylindole (DAPI) staining. By using the optical density method and coming into direct touch with gram-positive and gram-negative bacteria, the PCL/TiO2 scaffold exhibits antibacterial action. These data suggest that engineered nanocomposite scaffold has a superior potential for wound healing applications which improves elasticity, strength, and antibacterial properties.

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