PS-C09-7: PREVALENCE OF CHRONIC KIDNEY DISEASE IN ARTERIAL HYPERTENSION

Purpose: To study the prevalence of chronic kidney disease (CKD) markers in patients with arterial hypertension (AH). Materials and Methods: A retrospective analysis of 188 case histories of patients with AH of 1–3 degrees (ESC/ESH, 2018) who received inpatient treatmentwas carried out. Mean age 62.8 ± 10.2 years. All patients underwent determination of creatinine, GFR by EPI, uric acid, blood lipids. CKD stages were established according to the modern KDIGO 2013 classification. Results: Among the examined patients there were 18% patients with CKDC1, GFR> 90 (n = 34); 56.3% patients with CKDC2, GFR 60–89 (n = 106); 17.5% patients with CKDC3A, GFR 45–59 (n = 33); 5.3% patients with CKDC3B, GFR 30–44 (n = 10); 2.6% patients with CKDC4, GFR 15–29 (n = 5) (p < 0.00001). 98.4% of the examined patients suffered from coronary artery disease; 46.1% had diabetes mellitus. It should be noted that patients with stage 4 CKD were significantly older (55 ± 8 vs 62 ± 9 vs 68 ± 8 vs 69 ± 9 vs 74 ± 16; p < 0.00001). According to the level of SBP, DBP, heart rate, the patients did not differ significantly. SBP was: 134.5 ± 29.3 vs 134.1 ± 31.5 vs 132.5 ± 20.8 vs 138.2 ± 19.4 vs 156 ± 39.1 (p < 0.26). DBP was 87 ± 11.5 vs 84.3 ± 10 vs 82 ± 10 vs 86.3 ± 9.2 vs 90 ± 17.39 (p < 0.25). Patients with stage 4 CKD had severe abdominal obesity. WC: 102.4 ± 10 vs 104.7 ± 13.6 vs 103.2 ± 10.7 vs 101.5 ± 12.4 vs 110 ± 27.3 (p < 0.68). Mean creatinine in the groups was 70.6 ± 14.7 vs 85.2 ± 14.4 vs 102.3 ± 14.6 vs 121.6 ± 25.3 vs 209.6 ± 45.5 (p < 0.00001). Mean eGFR 98.2 ± 7.3 vs 72.9 ± 7.4 vs 53.7 ± 4.2 vs 37.5 ± 4.1 vs 22.6 ± 3.8 p (p < 0.00001). The analysis showed that as the stage of CKD increases, the level of microalbuminuria increases. Thus, MAU indicators were 31.05 ± 25.5 vs 41.6 ± 50.2 vs 38.6 ± 46 vs 96.6 ± 144.7 vs 308.8 ± 147.5 (p < 0.00001). It should be noted, that the high stages of CKD are characterized by significantly more pronounced asymptomatic hyperuremia. At the same time, the level of uric acid in group I was 5.4 ± 1.4 vs 6.5 ± 4.7 vs 6.5 ± 1.7 vs 7.5 ± 1.7 vs 7.8 ± 1.01 (p < 0.00001). Conclusion: Among patients with hypertension, the prevalence of CKD is significantly high (82%), which additionally increases the cardiovascular risk of this category of patients.

Ҳали таржима қилинмаган