REVIEW OF THE LITERATURE ON THE POTENTIAL EFFECT OF ANTIEPILEPTIC DRUGS ON THE BONE SYSTEM

This publication discusses the adverse effects of antiepileptic drugs on bone tissue, which increase the risk of fractures in patients with epilepsy compared with the general population. Many studies have shown a decrease in bone mineral density, an increase in the risk of osteopenia and osteoporosis in patients receiving traditional and new AEDs. Polytherapy and duration of AED use are associated with the most significant risk of decreased bone mineral density. Nevertheless, the molecular mechanisms of the effect of various AEDs on bone tissue remain poorly understood.

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