PB2635: FEATURES OF PLATELET PATHOLOGY IN PREGNANT WOMEN

Topic: 32. Platelet disorders Background: Thrombocytic pathologies are one of the most widespread diseases today and are considered to be one of the most pressing problems of medicine that have not been completely solved in terms of origin, pathogenesis, laboratory diagnosis and treatment. Thrombocytopenia and thrombocytopathies are polyethiological diseases, the origin of these pathologies during pregnancy remains unknown. In these pathologies, the nature of bleeding varies, being diseases that accelerate and lead to severe complications in the mother and child Aims: Study of the features of rejection of thrombocyte pathologies in pregnant women Methods: The analysis was carried out during 2021-2023 in 405 patients undergoing inpatient treatment in the Departments of pathology, resuscitation and childbirth of the multidisciplinary clinic of the Tashkent Medical Academy. The study involved patients aged 18 to 47 years (30.4±5.6) Results: In the study, the platelet pathologies identified in pregnant women were studied etiologically into 6 groups: idiopathic thrombocytopenic purpura 20.2% (n=82), immune thrombocytopenia 23.2% (n=94), symptomatic thrombocytopenia 4% (n=17), with thrombocytopenic syndrome in patients who underwent covid 7.9% (n=32), acquired thrombocytopathy 38% (n=154) and 6.4% (N=26) with thrombocytopathy syndrome. In the analysis of obstetric Anamnesis, 5% were found in pregnant women with thrombocyte pathologies; 21/405 women) had spontaneous abortion (undeveloped pregnancy), spontaneous abortion in the control group of women (undeveloped pregnancy) was 3.3% (/130) (p=0.02). As a result of the Anamnesis study, cases of premature placental abruption, usually located, were recorded only in pregnant women with thrombocyte pathologies (7% also found 28/405 cases), while no such cases were recorded in the control group of physiological pregnant women (0/30) (p=0.012). The history of early childbirth in pregnant women suffering from thrombocytic pathologies (4.7%; 19/405 women) statistically significantly exceeded the indicators in the control group (0/30) (p=0.007) of women examined. Cases of Antenatal and intranatal fetal death were detected in a group of pregnant women (1.5%; 6/405 women) with thrombocyte pathologies (p>0.05). When assessing the ratio of coefficients, it was found that pregnant women with thrombocyte pathologies have 2.87 times more (95% CI 1.17-7.03) than physiologically healthy pregnant women. Pregnant women with thrombocyte pathologies have a 13.5 times higher chance of preterm birth than physiologically healthy pregnant women (95% CI 0.81-224.87) and a 12.48 times higher chance of developing premature placental abruption with a normal platelet count than pregnant women (95% CI 0.75-208.09). Summary/Conclusion: The results of the study showed that in 361 of the 405 patients identified in total, hemorrhagic syndrome was observed, 56.5% of patients had nosebleeds (n=204), 32.4% (n=117) had milk bleeding, 52% (N=188) had uterine bleeding, and 17.5% (n=63) had skin bruises detected (p0,001). Keywords: Platelet function, Aggregation, Platelet count, Anti-platelet antibody

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