PROSPECTS FOR THE USE OF MEDICINAL PRODUCTS BASEDON PLANTS OF THE GENUS FERULA OF THE FLORA OF UZBEKISTAN

Ferula tadshikorum is a perennial, unpleasant-smelling herbaceous plant of the celery family -Apiaceae (Umbelliferae).In Uzbekistan, it grows in Kashkadarya, Surkhandarya regions.In folk medicine of the East, F. tadshikorum is used as an antiparasitic, anticonvulsant, antispasmodic, expectorant, for tuberculosis, syphilis, malignant tumors and to improve digestion.Of all the varieties of known types of feruleaaactivity, a promising direction of use in medicine is their antiparasitic, namely anti-lambliosis activity.It is known that giardiasis is a widespread disease, especially in children, which is promising for the Central Asian region.It is known from the literature that in the East, thetis resin ("smelly resin"), obtained from fresh Ferula roots by cutting, is used as a spice.Currently, industrial preparationsof this resin, which is exported by tons as a spice to India, Iran, Pakistan, Afghanistan,lead to depletion of stocks of these plants.The creation of new estrogenic herbal preparations based on the domestic Ferula species for the treatment of gynecological diseases is justified.Almost half of womenwith menopausal syndrome have a severe course of the disease (51%).In this regard,the development of a phytopreparation for the correction of menopausal syndrome based on the aboveground part of F. tenuisecta is relevant.The drug Tefestrol based on finely dissected Ferula (roots), which is used for the treatment of gynecological diseases in the form of 0.005 g tablets, has been introduced into medical practice in the Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan (IPS).But today, other medicinal forms of the drug are necessary and in demand in gynecological practice.One of the effective forms are: injection (oil solution), as well as ointment, which are especially effective in gynecology as a birth aid.It is known that cases of non-openingof the cervix are observed during childbirth, which leads to the need to use a caesarean section to prevent the death of the fetus.For the first time, we experimentallyestablished the effective use of an injectable oil solution of Tefestrol, which causes a smooth and complete opening of the cervix and successful natural childbirth.Within the framework of this scientific and technical project it is planned: on the basisof an alcohol extract and Ferula tadshikorum resin, to develop a technology of medicines with antiparasitic (anti-lambliosis) activity, estrogenic drugs (Tefestrol + oil solution for injection) as a birth aid (instead of "cesarean section"), a new phytopreparation forthe correction of menopausal syndrome and hormonal therapy from the aboveground part of the finely dissected ferula, an anti-inflammatory dietary supplement (dietary supplement) based on F. tadshikorum resin, proposed for use in gastrointestinal tract problems, as well as the development of a modern method of standardization of F. tadshikorum resin exported abroad.

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