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Luteolin and its analog luteolin-7-methylether from Leonurus japonicus Houtt suppress aromatase-mediated estrogen biosynthesis to alleviate polycystic ovary syndrome by the inhibition of tumor progression locus 2

Xiaoke ShiCenter for Natural Products Research, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaTing PengCenter for Natural Products Research, Chinese Academy of Sciences, Chengdu 610041, China; Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, ChinaBahtigul AzimovaDepartment of Inorganic, Physical and Colloidal Chemistry, Tashkent Pharmaceutical Institute, 45 Aybek Street, 100015, Tashkent, UzbekistanXiaoli LiKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, China. Electronic address: [email protected]Shanshan LiCenter for Natural Products Research, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaDongyi CaoCenter for Natural Products Research, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China; Department of Pharmacy, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming 650500, ChinaNaijie FuCenter for Natural Products Research, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaGuolin ZhangCenter for Natural Products Research, Chinese Academy of Sciences, Chengdu 610041, ChinaWei‐Lie XiaoKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming, ChinaFei WangCenter for Natural Products Research, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address: [email protected]
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