PCOS in women with infertility and role of determinant genes of steroid hormones

We observed 125 women: group 1 - 45 women with primary PCOS and infertility; group 2 - 46 women with infertility and PCOS in preparation for ART; group 3 26 conditionally healthy women. Based on the foregoing, we presented the data of our own studies on the assessment of the state, the genes of steroid hormones (CYP17A1-rs743572, CYP19A1-rs247015) based on the analysis of laboratory data. CY17A1 polymorphism in patients with PCOS, it can be said that the GG mutant genotype was statistically significantly more common in patients compared to the control group. When dividing PCOS patients, they were divided into groups and compared with the control group, MS+ PCOS patients had a lower level of the mutant form (GG) genotype compared to the control group, but in MS- PCOS patients compared to the control group, the mutant gene was determined more.

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