Мақола

Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review

Hussam Elddin Nabeih KhasawnehChemical Engineering Department, Huson University College, Albalqa Applied University, Salt, JordanAli Abdulrazzaq Abdulhussein AlrikabiCollege of Medicine, University of Thi-Qar, IraqAmran M. AL-ErjanDepartment Of Medical Lab. Technology, Mazaya University College, Dhi Qar, IraqMustafa Jawad KadhamCollege of Medical Techniques, Al-Farahidi University, Baghdad, IraqRaed Fanoukh Aboqader Al-AouadiCollege of Medicine, Al-Ayen Iraqi University, An Nasiriyah, IraqNatrayan LakshmaiyaDepartment of Research and Innovation, Saveetha School of Engineering, SIMATS, Chennai 602105, Tamilnadu, IndiaRoziyeva MuhayyoDepartment of Psychology and Medicine, Mamun university, Khiva, UzbekistanStefan BräseInstitute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, 76131 Karlsruhe, GermanyHadeer M. FarhanDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, Egypt

Results in Chemistryjournal2025en

ABI

Аннотация

1,2,4-Oxadiazole derivatives, a prominent class of nitrogen-containing heterocycles, have gained considerable attention recently due to their broad spectrum of biological activities. This review focuses on the most recent developments (2018–2024) in the exploration of their therapeutic potential. Studies have highlighted the efficacy of 1,2,4-oxadiazole derivatives in multiple domains, including anticancer, antimicrobial, antidiabetic, anti-inflammatory, and neuroprotective applications. These compounds have demonstrated promising results, particularly in combating drug-resistant pathogens, managing metabolic disorders, and offering potential treatments for neurodegenerative diseases. With a growing body of research supporting their diverse biological roles, 1,2,4-oxadiazole derivatives continue to be a significant focus in drug discovery and development. This review compiles key findings from recent studies, offering insights into their therapeutic applications and potential future directions for research.

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Мавзулар

Synthesis and biological activity Click Chemistry and Applications Synthesis and Biological Evaluation

Идентификаторлар

DOI: 10.1016/j.rechem.2025.102271

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