Мақола

Physicochemical Properties of a Water-Soluble Adduct of C<sub>60</sub> with <scp>l</scp>-Cysteine for Biomedical Applications

Konstantin N. SemenovInstitute of Chemistry, Saint Petersburg State University, 26 Universitetskii Prospect, Saint Petersburg 198504, RussiaAli MlhemSt. Petersburg State Institute of Technology (Technical University), Moskovskii pr. 26, Saint Petersburg 190013, RussiaAlexander V. AkentievPavlov First Saint Petersburg State Medical University, 6−8 L’va Tolstogo Street, Saint Petersburg 197022, RussiaDmitry NerukhAston UniversityNatalia V. PetukhovaPavlov First Saint Petersburg State Medical University, 6−8 L’va Tolstogo Street, Saint Petersburg 197022, RussiaIlnaz T. RakipovDepartment of Physical Chemistry, Kazan Federal University, Kremlevskaya Street 18, Kazan 420008, RussiaKirill V. TimoshchukPavlov First Saint Petersburg State Medical University, 6−8 L’va Tolstogo Street, Saint Petersburg 197022, RussiaGleb O. IurevInstitute of Chemistry, Saint Petersburg State University, 26 Universitetskii Prospect, Saint Petersburg 198504, RussiaAndrey V. PetrovInstitute of Chemistry, Saint Petersburg State University, 26 Universitetskii Prospect, Saint Petersburg 198504, RussiaI. V. MurinInstitute of Chemistry, Saint Petersburg State University, 26 Universitetskii Prospect, Saint Petersburg 198504, RussiaН. А. ЧарыковSt. Petersburg State Institute of Technology (Technical University), Moskovskii pr. 26, Saint Petersburg 190013, RussiaDilafruz K. KholmurodovaScientific and Practical Center of Immunology, Allergology and Human Genomics, Samarkand State Medical University, Amir Temur Street, 18, Samarkand 140100, UzbekistanLola B. MahmudovaSamarkand State Medical University, Amir Temur Street, 18, Samarkand 140100, UzbekistanGulafzal U. AmonovaSamarkand State Medical University, Amir Temur Street, 18, Samarkand 140100, UzbekistanDilfuza RabbimovaSamarkand State Medical University, Amir Temur Street, 18, Samarkand 140100, UzbekistanVladimir V. SharoykoInstitute of Chemistry, Saint Petersburg State University, 26 Universitetskii Prospect, Saint Petersburg 198504, Russia

The Journal of Physical Chemistry Lettersjournal2025en

ABI

Аннотация

As a result of a comprehensive study of the physicochemical properties of the C60-l-cysteine aqueous solutions, practically significant results were obtained, which underlie the understanding of the mechanisms of biological action and biocompatibility. It was shown that the adduct of fullerene C60 with l-cysteine is compatible with water and aqueous solutions and at the same time is amphiphilic. Aqueous solutions are strongly associated and, depending on the concentration, associates of various orders are formed up to the micron size; dilute solutions have high negative partial volumes, which indicate a strong structure. The adduct does not exhibit cytotoxicity, possesses antiradical activity, and reversibly binds to human serum albumin. The obtained data demonstrates the complexity of the systems under study and the prospects for their application in medicinal chemistry and biomedical materials science.

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Мавзулар

Fullerene Chemistry and Applications Carbon Nanotubes in Composites thermodynamics and calorimetric analyses

Идентификаторлар

DOI: 10.1021/acs.jpclett.5c01859

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