Study of cardiotonic activity of the triterpene compound cycloseversioside F from the plant Astragalus pterocephalus

Introduction. A current problem is the increase in the incidence of cardiovascular diseases (CVD) due to the growing prevalence of CVD risk factors, the intense pace of life, and the increasing proportion of the elderly population. Studies conducted in Russia, Western Europe, and the United States have shown that, despite the widespread introduction of fairly effective means of treating chronic heart failure in medical practice, the mortality rate of patients within a year in this population remains high. Based on the above, the author M.A. Agzamova isolated a triterpene compound, Cycloseversioside F, from the plant Astragalus pterocephalus, which has a potential cardiotonic effect. Objective: was to study the cardiotonic activity of the triterpene compound Cycloseversioside F from the plant Astragalus pterocephalus. Material and methods. The study of cardiotonic activity was carried out on a model of chronic heart failure caused by the introduction of mesaton, followed by dynamic physical exercise. The reference drug with a metabolite effect, «Meldonium» capsules 500 mg, was chosen as a reference drug. Results. The results of the study showed that the test preparation has reliable cardiotonic activity, which is manifested in the normalization of the heart weight coefficient, in the normalization of biochemical parameters of blood serum (lactodehydrogenase, creatine kinase MB and sodium). At the same time, a comparative study of the cardiotonic activity of the test preparation with the reference cardiac metabolite showed that the test preparation is not inferior to the reference drug in cardiotonic activity, and in some cases even surpasses it. The most effective dose was also found – 1000 mg/kg, and the obtained data on such effective doses as ED30 400 mg/kg, ED50 445 mg/kg and ED100 1000 mg/kg, can serve as a basis for calculating starting and subsequent doses for clinical studies. Conclusion. The studied triterpene series compound cyclosiversioside F from the plant Astragalus pterocephalus has reliable cardiotonic activity, which is not inferior to the reference drug, and in some cases superior.

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