Effect of polyphenol YaN-1, a Diazoimino derivative of gossypol, on the membrane of Cardiac Mitochondria

In this article, the effect of the diazoimino derivative gossypol [(((4,4'-bis((1,5-dimetil-3-okso-2-fenil-2,3-digidro-1H-pirazol-4-il) diazenil)-1,1',6,6'-tetragidroksi-5,5'-diizopropil-3,3'-dimetil-7,7'-diokso-[2,2'-binaftalin]-8,8'(7H,7'H)-diiliden)bis(metanililiden))bis(azanedil))bis(etan-2,1-diyl) bis(vodorod sulfat))] (YaN-1) on the swelling of cardiac mitochondria, the conductivity of the mitoKATP channel, and the lipid peroxidation process were determined by recording changes in optical density on a spectrophotometer. Polyphenol YaN-1, diazoimino derivative of gossypol, inhibited mPTP in rat heart mitochondria, causing an increase in the activity of mitoKATP channels compared to the control. It was established that the polyphenol YaN-1 has antioxidant properties, reducing the intensity of the lipid oxidation process in the inner and outer membranes of mitochondria.

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