Мақола

Chemical Constituents from Euphorbia esula

Defeng YanState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, ChinaMiaomiao ZhangState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, ChinaYuqing SongState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, ChinaLiu LiuState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, ChinaNurmirza BegmatovS. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 77, M. Ulugbek Str., Tashkent 100170, UzbekistanOrzimat T. TurginovInstitute of Botany, Academy of Sciences of the Republic of Uzbekistan, Tashkent 100047, UzbekistanBo ZhaoXinjiang Technical Institute of Physics & ChemistryHequn YangState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, ChinaGuo‐An ZouState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China

Plantsjournal2025en

ABI

Аннотация

Euphorbia esula is widely distributed across China, Central Asia and other regions worldwide. For centuries, it has been applied in folk and traditional medicine as a cure for diverse ailments. Nevertheless, the bioactive components responsible for anti-inflammatory and cytotoxic effects remain incompletely identified. In this study, two undescribed chemical constituents, a pyrrole alkaloid (1) and a loliolide analogue (2), alongside nine known components (3–11) were separated from the aerial parts of Euphorbia esula indigenous to Uzbekistan. Their chemical structures were comprehensively elucidated utilizing HRESIMS, NMR, IR and UV spectroscopy. Corresponding absolute configurations were determined based on comparison of experimental and calculated ECD data. Compounds 3–11 were firstly isolated from Euphorbia esula, among which 4, 5, 7 and 9–11 were yielded from the genus Euphorbia for the first time. Chemically, the discovery of various skeletons covering pyrrole alkaloids (1, 9), norisoprenoids (2–8), furanone (10) and unusual cyclooct-2-enone (11) particularly highlighted the structural diversity. Bioactivity assays revealed that some compounds (1, 3, 5, 6, 7 and 8) exhibited certain anti-inflammatory effects via inhibiting the NO release in LPS-induced RAW 264.7 macrophages.

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Мавзулар

Bioactive Natural Diterpenoids Research Phytochemistry and Biological Activities

Идентификаторлар

DOI: 10.3390/plants14182822

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