Antiproliferative and Apoptotic Effects of <i>Lavandula officinalis</i> In Vitro by Inhibiting HeLa Cancer Cell Growth and Migration

The most prevalent cancer in women is cervical cancer, which is impacted by lifestyle choices, inadequate healthcare, and HPV exposure. The medicinal qualities of lavender, or Lavandula officinalis, include antibacterial, anti-inflammatory, and antioxidant actions. The antiproliferative and apoptotic effects of lavender on HeLa cervical cancer cells were evaluated in this study with doses ranging from 100 to 500 µg/mL. The results indicated that cell viability had significantly decreased (94.1 ± 7, 53.4 ± 4, 36.3 ± 2, respectively, p < 0.05). At 400 and 500 µg/mL, lavender inhibited bigger lesions and boosted apoptosis. MMP-2 expression dropped by 9%, 19%, 38%, and 58% at the same concentrations, whereas caspase-3 expression rose by 8%, 50%, 90%, and 110% at 200-500 µg/mL. According to these results, lavender may prevent cervical cancer from growing, migrating, and spreading.

Ҳали таржима қилинмаган