SPECIFIC FEATURES OF BRONCHIAL ASTHMA ASSOCIATED WITH ATOPIC DERMATITIS IN CHILDREN LIVING IN THE KHOREZM REGION

Bronchial asthma and atopic dermatitis occupy a leading place among chronic allergic diseases of childhood. Their prevalence worldwide shows a steady upward trend, which is associated with changes in the ecological situation, lifestyle, and the influence of urbanization. Objective: to study the clinical, immunological, and regional features of the comorbid course of bronchial asthma and atopic dermatitis in children living in the Khorezm region. Materials and Methods. The study was conducted on the basis of pediatric departments of the Khorezm region and the Department of Children’s Diseases of the Tashkent State Medical University. A total of 120 children aged 6 to 15 years, permanently residing in the Khorezm region, were included in the study. Results. The average age of onset of bronchial asthma in children with comorbid course was 5.2 ± 0.8 years, which was significantly earlier than in children with isolated asthma (7.1 ± 0.9 years, p < 0.05). Patients with BA+AD had a higher number of nocturnal coughing episodes (5.6 episodes/month on average) compared to those with isolated BA (3.1 episodes/month). The total number of exacerbations per year was also higher in children with the comorbid course (3.8 ± 0.6 vs. 2.1 ± 0.4, p < 0.01). Conclusion. In children of the Khorezm region, the comorbid course of bronchial asthma and atopic dermatitis is characterized by an earlier onset, more frequent exacerbations, and a pronounced immunological imbalance with predominance of the Th2 response, which determines a severe recurrent course and requires an individualized therapeutic approach.

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