The effect of optical signal amplification methods on ion-selective electrodes for the detection of dibazol and pyridoxine

Recent developments in ion-selective electrode (ISE) technology suggest the potential for enhancing sensor performance through integration with photonic materials and optical systems. This approach could significantly improve the detection capabilities of ISEs, especially for low-concentration ions. The chemical and pharmaceutical industries, as well as the extensive network of pharmacy departments at all levels, and finally, pharmacies themselves, require fast, accurate, and straightforward methods for identifying medicinal substances. Therefore, information about ionometric methods for determining various medicinal substances is of particular interest. Over the past 15–20 years, researchers have focused on developing and studying ion-selective electrodes (ISEs) that respond to pharmaceutical agents and applying them in biological systems. Currently, reliable ion-selective electrodes have been proposed for analyzing many medicinal substances, significantly simplifying analytical practices while providing high sensitivity and low measurement error. The purpose of this work is to develop solid-state ISEs responsive to the ions of novocain, lidocaine, drotaverine, and diphenhydramine, and to study their characteristics.

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