Improving Methods For Diagnosing Endocrine Infertility

Endocrine infertility is one of the most common forms, the origin of which is directly related to a decrease in ovarian reserve, hormonal imbalance, metabolic changes, and immunological factors. Functional disorders in the endocrine system disrupt the maturation process of egg cells, cause ovulation to fail, and this causes serious problems in restoring fertility in women Objective: In the early diagnosis and prognosis of women with endocrine infertility, the level of expression of epigenetic markers Let-7b-5p, miR-223-3p, and miR-320a was studied, and their pathogenetic relationship with clinical, hormonal, and echographic indicators was proven. Results: This study is distinguished by the fact that it covers biomarker-based approaches in the diagnosis of women with infertility of endocrine genesis, and this algorithm is important for restoring fertility and improving the resultsThe introduction of differentiated, pathogenetically based, and individualized approaches to cases of infertility of endocrine origin not only increased clinical effectiveness, but also provided a wide range of social and economic benefits. According to the results of the study, in women with infertility against the background of hyperprolactinemia, hypothyroidism, and ovarian dysfunction, against the background of targeted therapy (cabergoline, tyramine, ovariamine), the frequency of ovulation and pregnancy significantly increased (56.7-66.7% and 33.3-40.0%, respectively). Conclusions:The introduction of differentiated, pathogenetically based, and individualized approaches to cases of infertility of endocrine origin not only increased clinical effectiveness, but also provided a wide range of social and economic benefits. this study is distinguished by the fact that the diagnosis of women with infertility of endocrine genesis includes individual, biomarker-based approaches, which is important for the restoration of fertility and improvement of results.

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