CYTOMEGALOVIRUS ETIOLOGY OF HEPATITIS IN CHILDREN

CYTOMEGALOVIRUS ETIOLOGY OF HEPATITIS IN CHILDREN Yusupova Nargiza Abdikodirovna, Manonova Nigina Oktamovna, Rakhmatova Munira Fakhriddin qizi, Esonkulova Iroda Olimjon qizi, [email protected] Department of Clinic laboratory diagnostic of Samarkand State Medical University. Uzbekistan, Samarkand city, Amir Temur street 18, Tel: +998 66 2330841 E-mail: [email protected]. https://doi.org/10.5281/zenodo.18261295 АННОТАЦИЯ: Relevance. The article presents an analysis of the structure of viral hepatitis in children, among which cytomegalovirus (CMV) hepatitis as a monoinfection was diagnosed in 8 children (3.4%), and mixed infection in 10 patients (4.3%). Clinical observations of CMV hepatitis in children of different ages are presented, demonstrating different course variants: acute CMV hepatitis, ending in recovery in a 12-year-old child, and primary chronic in a 5-month-old child. The aim of the study was to analyze the etiological structure of CMV hepatitis in children. To study the clinical variants of the course of CMV hepatitis. Materials and methods. The etiological structure of VG was studied using the materials of the Kharkiv Regional Children's Infectious Diseases Clinical Hospital (RCIDCH). The development included the medical records of 236 children aged from 1 month to 17 years who were inpatients during the period 2013–2017. Results. Analysis of the etiologic structure of viral hepatitis in children showed that HAV occupies the leading place (38.1%), acute hepatitis B and chronic hepatitis B accounted for 13.6 and 15.7%, respectively. Chronic hepatitis B + D was diagnosed in one child. Chronic hepatitis C was observed in 22 (9.3%) patients. The etiologic structure of viral hepatitis was not limited to known hepatotropic pathogens, and in 18 (7.6%) children the results of laboratory methods of etioverification were negative. Hepatitis of specified etiology was mainly represented by mono- or mixed herpesvirus infection, which was diagnosed in 15 (6.4%) patients. Conclusion. In the structure of viral hepatitis, CMV hepatitis as a monoinfection was diagnosed in 3.4% of cases, in association with other pathogens - in 4.3%. CMV hepatitis can occur in an acute form, reactivated against the background of a persistent chronic infection, or in a primary chronic form. Depending on the time of infection, congenital and acquired forms of the disease are distinguished. Keywords: cytomegalovirus; children; hepatitis

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