SOD2 AND eNOS GENE POLYMORPHISMS AS PREDICTORS OF OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION IN CYTOMEGALOVIRUS INFECTION

Genotyping was performed in 100 patients with CMV infection (Group I - latent form, Group II - manifest persistent form) and 80 individuals of the control group. It was established that the Val/Val genotype of the SOD2 gene (39.6% vs. 22.5%; OR=2.27; p=0.03) and the T allele of the eNOS gene (36.2% vs. 19.4%; OR=2.47; p=0.001) are significantly associated with the risk of infection manifestation. The highest increase in the risk allele frequency was recorded for the SOD2 polymorphism (Δ16.3%), indicating the key role of antioxidant defense deficiency in the pathogenesis of persistence. The findings justify the inclusion of oxidative stress and endothelial dysfunction markers into a prognostic panel for assessing the risk of CMV progression.

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