PREMALIGNANT PATHOMORPHOLOGY OF THE LIVER IN CHRONIC HEPATITIS C: CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL CORRELATIONS

Background: Chronic hepatitis C (CHC) remains an important etiological factor for liver cirrhosis and hepatocellular carcinoma (HCC). Premalignant morphological changes in the liver are mediated by progressive fibrosis, necroinflammatory activity, immune-cell infiltration, and activation of Kupffer cells and hepatic stellate cells [1–4].

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