Design Of Bioadhesive Transdermal Patches Using Chitosan– Cellulose Nanocomposites For Anxiolytic Drug Delivery

Transdermal drug delivery systems have emerged as an effective alternative to conventional oral administration for improving therapeutic efficacy and patient compliance. The present study focuses on the design and evaluation of bioadhesive transdermal patches based on chitosan–cellulose nanocomposites for the controlled delivery of anxiolytic drugs. Chitosan, a biodegradable and biocompatible polymer with inherent bioadhesive and permeation-enhancing properties, was combined with cellulose nanomaterials to enhance mechanical strength and drug release performance. The nanocomposite patches were prepared using a solvent casting method and characterized for physicochemical properties including thickness, tensile strength, folding endurance, and surface morphology. Drug–polymer compatibility was assessed using FTIR and DSC analysis. In vitro drug release and permeation studies demonstrated sustained and controlled release behavior, following diffusion-controlled kinetics. The incorporation of cellulose nanostructures improved the structural integrity and stability of the patches while maintaining optimal bioadhesion. The developed system offers a promising non-invasive approach for the delivery of anxiolytic agents, minimizing first-pass metabolism and reducing dosing frequency. Overall, chitosan–cellulose nanocomposite-based bioadhesive patches represent a potential platform for effective and sustained transdermal therapy in anxiety management.

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