Assessment of Neurospecific Metabolites State Under Experimental Immobilization Stress

The leading pathogenetic mechanisms of stress development are associated with deterioration of human functional state, subsequent decrease in work performance, and disease development. The relevance of studying immobilization stress and using the ELI-Neuro-Test is driven by the need to understand the mechanisms of organism adaptation to extreme exposures and to diagnose early pathological changes. The most promising markers for identifying changes associated with chronic immobilization stress are antibodies to NF-200 and antibodies to the voltage-gated calcium channel (V-GCC). These assessment criteria will be more informative when included in a multifactorial diagnostic panel.

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