Clinical Features Of Cytomegalovirus Infection In Patients With Hiv Infection

Relevance. According to WHO, mortality from herpes infection is in second place among viral diseases (15.8%) after hepatitis (35.8%) [1]. Cytomegalovirus (CMV) is an important human pathogen that causes a variety of syndromes, from asymptomatic infections to life-threatening lesions. Objective: to study the role of cytomegalovirus infection as an etiological factor of colitis in HIV-positive patients. Materials and methods: The study was conducted on the basis of a specialized clinic for infectious diseases of the Republican AIDS Center, 65 patients were examined. By gender, the patients were distributed as follows: 48 men (73.8%) and 17 women (26.1%), 49 (75.3%) patients aged 18 to 35 years, 16 patients aged 36-60 years ( 24.6%). Results of the study and their discussion: The study confirms the role of CMV infection in the occurrence of colitis and ongoing diarrhea in HIV-positive patients. After a course of therapy with Ganciclovir, a decrease in disease activity was noted, stool became less frequent, and during colonoscopy: pronounced positive dynamics in the form of partial closure of ulcerative defects and patency of intestinal strictures. Immunohistochemical study of colon biopsies revealed a significant decrease in the expression of cytomegalovirus. Conclusions: Thus, CMV infection may be a cause of diarrhea in patients with HIV infection. Detection of CMV infection requires consideration of the issue of prescribing antiviral therapy (Ganciclovir) in combination with ART

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