ASSOCIATION BETWEEN RENAL DYSFUNCTION MARKERS AND FREQUENT SUPRAVENTRICULAR EXTRASYSTOLES IN PATIENTS WITH ARTERIAL HYPERTENSION

Objective: To assess the relationship between renal function indicators (GFR and serum creatinine levels) and frequent supraventricular extrasystoles (FSVE) in patients with arterial hypertension (AH). Design and method: The study included 50 patients with AH (grades I–III) with high or very high cardiovascular risk. The mean age was 51.2 ± 11.9 years, and the average duration of hypertension was 8.8 ± 6.2 years. All patients underwent 24-hour Holter ECG monitoring to detect cardiac rhythm disorders. Serum creatinine concentration was measured using an enzymatic method on a “Daytona TM” biochemical analyzer (Rendox, UK). Glomerular filtration rate (GFR) was calculated using the CKD-EPI equation. Statistical processing was performed using standard methods of descriptive statistics. Spearman correlation analysis was used to assess associations. Differences were considered statistically significant at p < 0.05. Results: Serum creatinine level correlated with FSVE (r = +0.38; p = 0.038), indicating increased arrhythmic activity with deterioration of renal function. GFR demonstrated a significant inverse correlation with FSVE (r = –0.50; p = 0.005): lower GFR values were associated with a higher frequency of supraventricular extrasystoles. These findings indicate a link between impaired renal filtration function and increased electrical instability of the atria. Conclusions: Renal function parameters are associated with FSVE in patients with arterial hypertension. Increased creatinine levels and reduced GFR may be considered potential predictors of the development and progression of supraventricular arrhythmias in this patient population.

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