STRATIFICATION OF PROATHEROGENIC POTENTIAL IN CHRONIC CORONARY SYNDROMES: SUPERIORITY OF APOLIPOPROTEIN B/A-I RATIO OVER TRADITIONAL LIPID METRICS IN THE UZBEK POPULATION

Abstract. This research aims to provide a comprehensive evaluation of the diagnostic utility of the apolipoprotein B (apo-B) to apolipoprotein A-I (apo-A-I) ratio as a superior risk stratification tool compared to traditional LDL-C in comorbid patients with coronary heart disease (CHD). 210 patients with functional class II-III exertional angina were examined. Results demonstrated that while standard lipidogram values (LDL-C 3.6 ± 0.1 mmol/l) classified patients as "borderline" risk, the apolipoprotein ratio (1.31 ± 0.01) revealed a critically high atherogenic potential. A significant influence of subclinical hypothyroidism (28.1% in women) and obesity on the formation of pathological apolipoprotein profiles was established. The study concludes that integrating apolipoprotein screening is essential for accurately determining residual cardiovascular risk and optimizing preventive therapy in regional clinical practice.

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