Volume Expansion Sensitivity of Swelling-Activated Cl- Channel in Human Epithelial Cells.
Shigeru MorishimaDepartment of Cell Physiology, National Institute for Physiological Sciences, Okazaki, 444-8585 JapanTakahiro ShimizuDepartment of Cell Physiology, National Institute for Physiological Sciences, Okazaki, 444-8585 Japan;Hajime KidaDepartment of Internal Medicine, Kyoto University Faculty of Medicine, Kyoto, 606-8501 JapanYasunobu OkadaCREST, Japan Sciences and Technology Cooperation, Okazaki, 444-8585 Japan;
2000en
ABI
Аннотация
In human epithelial cell lines, whole-cell swelling-activated Cl(-) current was not directly correlated to cell volume per se, membrane tension or hydrostatic pressure. The current density exhibited a relation described by a Boltzmann function to the square of the cell diameter. Cytochalasin D enhanced the volume sensitivity. These results suggest that the activation mechanism of volume-sensitive Cl(-) channel is related to cytoskeleton-dependent membrane spring energy in human epithelial cells.
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