Мақола

Prophylactic supplementation of resveratrol is more effective than its therapeutic use against doxorubicin induced cardiotoxicity

Heba Samy ShoukryDepartment of Physiology, Biochemistry and Histology, Faculty of Medicine, Cairo University, Cairo, EgyptHania Ibrahim AmmarDepartment of Physiology, Biochemistry and Histology, Faculty of Medicine, Cairo University, Cairo, EgyptLaila Ahmed RashedDepartment of Physiology, Biochemistry and Histology, Faculty of Medicine, Cairo University, Cairo, EgyptMaha Balegh ZikriDepartment of Physiology, Biochemistry and Histology, Faculty of Medicine, Cairo University, Cairo, EgyptAshraf Ali ShamaaDepartment of Surgery, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptSahar Gamal Abou elfadlDepartment of Physiology, Biochemistry and Histology, Faculty of Medicine, Cairo University, Cairo, EgyptEjlal Abu-Al RubSt. Boniface Hospital Research Centre, Department of Physiology, University of Manitoba, Winnipeg, CanadaSaravanan SekaranSt. Boniface Hospital Research Centre, Department of Physiology, University of Manitoba, Winnipeg, CanadaSanjiv DhingraSt. Boniface Hospital Research Centre, Department of Physiology, University of Manitoba, Winnipeg, Canada

2017en

ABI

Аннотация

Resveratrol (RSV), a polyphenolic compound and naturally occurring phytoalexin, has been reported to exert cardio-protective effects in several animal studies. However, the outcome of initial clinical trials with RSV was less effective compared to pre-clinical studies. Therefore, RSV treatment protocols need to be optimized. In this study we evaluated prophylactic versus therapeutic effect of resveratrol (RSV) in mitigating doxorubicin (Dox)-induced cardiac toxicity in rats. To investigate prophylactic effects, RSV was supplemented for 2 weeks along with Dox administration. After 2 weeks, Dox treatment was stopped and RSV was continued for another 4 weeks. To study therapeutic effects, RSV treatment was initiated after 2 weeks of Dox administration and continued for 4 weeks. Both prophylactic and therapeutic use of RSV mitigated Dox induced deterioration of cardiac function as assessed by echocardiography. Also RSV treatment (prophylactic and therapeutic) prevented Dox induced myocardial damage as measured by cardiac enzymes (LDH and CK-MB) in serum. Which was associated with decrease in Dox induced myocardial apoptosis and fibrosis. Interestingly our study also reveals that prophylactic use of RSV was more effective than its therapeutic use in mitigating Dox induced apoptosis and fibrosis in the myocardium. Therefore, prophylactic use of resveratrol may be projected as a possible future adjuvant therapy to minimize cardiotoxic side effects of doxorubicin in cancer patients.

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Идентификаторлар

DOI: 10.1371/journal.pone.0181535

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