Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins
M. S. RanjithFaculty of Medicine, Microbiology Unit, AIMST University, Kedah, MalaysiaA. J. A. RanjitsinghDepartment of Advanced Zoology and Biotechnology , Sri Paramakalyani College , Alwarkurichi ,S K ShankarAssociate Professor, Microbiology Unit , Faculty of Medicine , AIMST University , Bedong 08100 , Kedah , MalaysiaGS VijayalaksmiSri Paramakalyani Center for Environmental Sciences, M. S. University, Tirunelveli, IndiaK. DeepaFaculty of Medicine , Microbiology Unit , Anatomy Unit , AIMST University , Kedah , Malaysia,K. K. Raja BabuR and D Center , Cholayil Private Limited , Chennai , IndiaHarcharanHarcharan SidhuAssociate Professor, Microbiology Unit , Faculty of Medicine , AIMST University , Bedong 08100 , Kedah , Malaysia
2010en
ABI
Аннотация
Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranulation. Further, aqueous and alcoholic extracts of S. trilobatum significantly decreased the release of IL1α and increased the release of IL8 from the cultured keratinocytes. Oral administration of the aqueous and alcoholic extracts of S. trilobatum stabilized mast cells in experimental rats.
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