Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement
Deirdre Nolfi‐DoneganHeart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA; Department of Pediatrics, Division of Hematology/Oncology, Children's Hospital of Pittsburgh, Pittsburgh, PA, 15224, USAAndrea BraganzaHeart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USASruti ShivaHeart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA. Electronic address: [email protected]
2020en
ABI
Аннотация
The mitochondrial electron transport chain utilizes a series of electron transfer reactions to generate cellular ATP through oxidative phosphorylation. A consequence of electron transfer is the generation of reactive oxygen species (ROS), which contributes to both homeostatic signaling as well as oxidative stress during pathology. In this graphical review we provide an overview of oxidative phosphorylation and its inter-relationship with ROS production by the electron transport chain. We also outline traditional and novel translational methodology for assessing mitochondrial energetics in health and disease.
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