PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel
Junhua YangDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USAJianan ChenDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USAMaria del Carmen ViteryDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USAJames Osei‐OwusuDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USAJiachen ChuDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USAHaiyang YuLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USAShuying SunLieber Institute for Brain DevelopmentZhaozhu QiuDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
2019en
ABI
Аннотация
A new protein channel family Exposure of cells to acidic conditions outside the cell activates chloride-conducting channels that influence physiological and pathological processes. Yang et al. used an unbiased RNA interference screen to identify the channel protein that allows such proton-activated ion conductance. The protein, called PAC for proton-activated channel, has two predicted transmembrane domains and is unlike any previously identified channel. Identification of the channel should advance studies of its physiological roles, which range from tissue injury after stroke to adaptation of Tibetan natives to a high-altitude environment. Science , this issue p. 395
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