Investigation of Heck coupling on 6-bromo[2,3-d]thienopyrimidines for construction of new EGFR inhibitor lead structures

With the aim of identifying new lead structures for EGFR inhibition, a study of palladium catalysed Heck coupling between (<italic>R</italic>)-6-bromo-<italic>N</italic>-(1-phenylethyl)thieno[2,3-<italic>d</italic>]pyrimidin-4-amine and various acrylates was performed.

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