The Role of PTEN in Tumor Angiogenesis
Stéphane RodriguezDepartment of Clinical Research and Department of Nephrology and Hypertension, Inselspital, University of Bern Medical School, 3010 Bern, SwitzerlandUyen Huynh‐DoDepartment of Clinical Research and Department of Nephrology and Hypertension, Inselspital, University of Bern Medical School, 3010 Bern, Switzerland
2011en
ABI
Аннотация
During the past 20 years, the phosphatase and tensin homolog PTEN has been shown to be involved in major physiological processes, and its mutation or loss is often associated with tumor formation. In addition PTEN regulates angiogenesis not only through its antagonizing effect on the PI3 kinase pathway mainly, but also through some phosphatase-independent functions. In this paper we delineate the role of this powerful tumor suppressor in tumor angiogenesis and dissect the underlying molecular mechanisms. Furthermore, it appears that, in a number of cancers, the PTEN status determines the response to chemotherapy, highlighting the need to monitor PTEN expression and to develop PTEN-targeted therapies.
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