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Exosomal MicroRNAs: Novel Players in Cervical Cancer

Javid Sadri NahandDepartment of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IranNoushin Rezaei VandchaliDepartment of Biochemistry & Genetic, Faculty of Medicine, Arak University of Medical Sciences, Arak, IranHassan DarabiMedical Genetics Research Center, Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMohammad DoroudianDepartment of Cell & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, IranHamid Reza BanafsheDepartment of Pharmacology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IranMohsen MoghoofeiDepartment of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IranFarhad BabaeiDepartment of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IranArash SalmaninejadDepartment of Medical Genetics, Faculty of Medicine, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, IranHamed MirzaeiResearch Center for Biochemistry & Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

2020en

ABI

Аннотация

Cervical cancer ranks fourth for both mortality and morbidity in women globally. Exosomes are considered as extracellular vesicles, secreted continuously by many cells with a size range from 30 to 150 nm. Exosomes can encapsulate microRNAs (miRNAs) and release them for cellular communications. This exosome-induced miRNA transfer is a novel strategy for genetic exchange among cells. This trafficking modality affects many pathological as well as physiological conditions. Moreover, exosomes can protect the miRNAs against harsh environments and keep them very stable. Given that a variety of exosomal miRNAs derived from cervical cancer cells can be targeted to recipient cells and contribute to tumorgenesis, it has been documented that exosomal miRNAs could be applied as diagnostic and therapeutic biomarkers in the treatment of cervical cancer. Herein, we summarize the pathologic and diagnostic roles of exosomal miRNAs in the cervical cancer. Moreover, we highlight the roles of exosomal miRNAs in other cancers.

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Идентификаторлар

DOI: 10.2217/epi-2020-0026

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