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Hormonal Regulation of Hematopoietic Stem Cells and Their Niche: A Focus on Estrogen

Hye-Ryeon HeoDepartment of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, KoreaLi ChenCenter of Stem Cell and Regenerative Medicine, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, ChinaBorim AnDepartment of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, KoreaKye-Seong KimGraduate School of Biomedical Science and Engineering, Department of Biomedical Science, Hanyang University, Seoul, KoreaJunfeng JiCenter of Stem Cell and Regenerative Medicine, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, ChinaSeok‐Ho HongDepartment of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea

2015en

ABI

Аннотация

Self-renewal and differentiation are hallmarks of stem cells and controlled by various intrinsic and extrinsic factors. Increasing evidence indicates that estrogen (E2), the primary female sex hormone, is involved in regulating the proliferation and lineage commitment of adult and pluripotent stem cells as well as modulating the stem cell niche. Thus, a detailed understanding of the role of E2 in behavior of stem cells may help to improve their therapeutic potential. Recently, it has been reported that E2 promotes cell cycle activity of hematopoietic stem and progenitor cells and induces them to megakaryocyte-erythroid progenitors during pregnancy. This study paves the way towards a previously unexplored endocrine mechanism that controls stem cell behavior. In this review, we will focus on the scientific findings regarding the regulatory effects of E2 on the hematopoietic system including its microenvironment.

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DOI: 10.15283/ijsc.2015.8.1.18

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