Мақола

Interpolymer Complexes of Eudragit® Copolymers as Novel Carriers for Colon-Specific Drug Delivery

А. В. БуховецInstitute of Pharmacy, Kazan State Medical University, 16 Fatykh Amirkhan Street, 420012 Kazan, RussiaNikoletta FotakiDepartment of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UKVitaliy V. KhutoryanskiyInstitute of Pharmacy, Kazan State Medical University, 16 Fatykh Amirkhan Street, 420012 Kazan, RussiaRouslan I. MoustafineInstitute of Pharmacy, Kazan State Medical University, 16 Fatykh Amirkhan Street, 420012 Kazan, Russia

2020en

ABI

Аннотация

Interpolymer complexes (IPC) based on Eudragit® EPO and Eudragit® S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v) and tetrahydrofuran). According to the data of elemental analysis, FTIR-spectroscopy, X-ray photoelectron spectroscopy and thermal analysis these IPCs have excess of anionic copolymer (Eudragit® S100) in their structure; they are stabilized by hydrogen and ionic intermacromolecular bonds and do not include free copolymer domains. IPC have pH-independent swelling properties in the media mimicking gastrointestinal tract (GIT) conditions and provide colon-specific delivery of indomethacin in buffer solutions (pH 1.2; 5.8; 6.8; 7.4) and in biorelevant media (fasted state simulated gastric fluid, fasted state simulated intestinal fluid—version 2 and fasted stated simulated colonic fluid).

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Идентификаторлар

DOI: 10.3390/polym12071459

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