Мақола

Measurement and Modeling of the Solubility of Mebeverine Hydrochloride in Supercritical Carbon Dioxide

Seyed Ali SajadianDepartment of Chemical Engineering Faculty of Engineering University of Kashan Postal Code 87317‐53153 Kashan IranNadia EsfandiariDepartment of Chemical Engineering Marvdasht Branch Islamic Azad University Postal Code 73711‐13119 Marvdasht IranNedasadat Saadati ArdestaniDepartment of Chemical Engineering Faculty of Engineering Tarbiat Modares University Postal Code 14119‐44961 Tehran IranMitra AmaniDepartment of Chemical Engineering Islamic Azad University Robat Karim Branch Postal Code 37616‐16461 Robat Karim IranL. Antonio EstévezDepartment of Chemical Engineering University of Puerto Rico Mayagüez PR 00681‐9000

2024en

ABI

Аннотация

Abstract Mebeverine hydrochloride is an important drug to treat irritable bowel syndrome. The solubility of this drug in supercritical carbon dioxide was measured at temperatures from 35 to 65 °C and pressures from 12 to 30 MPa. Results were between 2.16 and 30.2 ppm by mole. The data were correlated with density‐based models (K‐J, MST, Chrastil, Garlapati and Madras, Bartle et al., and Sparks et al.) and equations of state (Peng‐Robinson, Soave, and Estévez et al. models). The mean relative deviation and corrected correlation coefficient were used to assess the goodness of the models. Based on all ten models, Sparks et al. performed best according to average absolute relative deviation (5.64 %), and Bartle et al. was the best according to R adj (0.997). However, this contribution's main merit is the reported experimental data.

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Идентификаторлар

DOI: 10.1002/ceat.202300449

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