Metabolism of Fluorine-Containing Drugs
Bongkyu ParkDepartment of Pharmacology and Therapeutics, New Medical Building, University of Liverpool, Liverpool, United Kingdom;, ,Neil R. KitteringhamDepartment of Pharmacology and Therapeutics, New Medical Building, University of Liverpool, Liverpool, United Kingdom;, ,Paul M. O’NeillDepartment of Pharmacology and Therapeutics, New Medical Building, University of Liverpool, Liverpool, United Kingdom;, ,
2001en
ABI
Аннотация
This article reviews current knowledge of the metabolism of drugs that contain fluorine. The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.
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