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Tailor-Made Polysaccharides for Biomedical Applications

Mohsen Khodadadi YazdiAdvanced Materials Center, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, PolandFarzad SeidiJiangsu Co−Innovation Center for Efficient Processing and Utilization of Forest Resources and International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, ChinaAleksander HejnaInstitute of Materials Technology, Poznan University of Technology, PL-61-138 Poznań, PolandPayam ZarrintajSchool of Chemical Engineering, Oklahoma State University, 420 Engineering North, Stillwater, Oklahoma 74078, United StatesNavid RabieeDepartment of Biomaterials, Saveetha Dental College and Hospitals, SIMATS, Saveetha University, Chennai 600077, IndiaJustyna Kucińska‐LipkaDepartment of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, 80-233 Gdańsk, PolandMohammad Reza SaebDepartment of Pharmaceutical Chemistry, Medical University of Gdańsk, J. Hallera 107, 80-416 Gdańsk, PolandSidi A. BencherifChemical Engineering Department, Northeastern University, Boston, Massachusetts 02115, United States

2024en

ABI

Аннотация

Polysaccharides (PSAs) are carbohydrate-based macromolecules widely used in the biomedical field, either in their pure form or in blends/nanocomposites with other materials. The relationship between structure, properties, and functions has inspired scientists to design multifunctional PSAs for various biomedical applications by incorporating unique molecular structures and targeted bulk properties. Multiple strategies, such as conjugation, grafting, cross-linking, and functionalization, have been explored to control their mechanical properties, electrical conductivity, hydrophilicity, degradability, rheological features, and stimuli-responsiveness. For instance, custom-made PSAs are known for their worldwide biomedical applications in tissue engineering, drug/gene delivery, and regenerative medicine. Furthermore, the remarkable advancements in supramolecular engineering and chemistry have paved the way for mission-oriented biomaterial synthesis and the fabrication of customized biomaterials. These materials can synergistically combine the benefits of biology and chemistry to tackle important biomedical questions. Herein, we categorize and summarize PSAs based on their synthesis methods, and explore the main strategies used to customize their chemical structures. We then highlight various properties of PSAs using practical examples. Lastly, we thoroughly describe the biomedical applications of tailor-made PSAs, along with their current existing challenges and potential future directions.

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DOI: 10.1021/acsabm.3c01199

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