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Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

Qingzhu ShiDepartment of Immunology, Institute of Basic Medical Research, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China; National Key Laboratory of Medical Immunology, Institute of Immunology, Naval Medical University, Shanghai 200433, ChinaQicong ShenYanfang LiuDepartment of Pathology, Changhai Hospital, Naval Medical University, Shanghai 200433, ChinaYang ShiDepartment of Immunology, Institute of Basic Medical Research, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China; National Key Laboratory of Medical Immunology, Institute of Immunology, Naval Medical University, Shanghai 200433, ChinaWenwen HuangInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, ChinaXi WangInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, ChinaZhiqing LiYangyang ChaiDepartment of Immunology, Institute of Basic Medical Research, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, ChinaHao WangDepartment of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, ChinaXiangjia HuNan LiQian ZhangNational Key Laboratory of Medical Immunology, Institute of Immunology, Naval Medical University, Shanghai 200433, China. Electronic address: [email protected]Xuetao CaoDepartment of Immunology, Institute of Basic Medical Research, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China; National Key Laboratory of Medical Immunology, Institute of Immunology, Naval Medical University, Shanghai 200433, China; Frontier Research Center for Cell Response, Institute of Immunology, College of Life Sciences, Nankai University, Tianjin 300071, China. Electronic address: [email protected]
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