Water-Soluble Green Perylenediimide (PDI) Dyes as Potential Sensitizers for Photodynamic Therapy
Funda YükrükDepartment of Chemistry, Middle East Technical University, Ankara, Turkey TR-06531, and Department of Basic Oncology, Oncology Institute, Hacettepe University, Sihhiye, Ankara, Turkey TR-06100A. Lale DoğanDepartment of Chemistry, Middle East Technical University, Ankara, Turkey TR-06531, and Department of Basic Oncology, Oncology Institute, Hacettepe University, Sihhiye, Ankara, Turkey TR-06100Hande CanpınarDepartment of Chemistry, Middle East Technical University, Ankara, Turkey TR-06531, and Department of Basic Oncology, Oncology Institute, Hacettepe University, Sihhiye, Ankara, Turkey TR-06100Dicle GüçDepartment of Chemistry, Middle East Technical University, Ankara, Turkey TR-06531, and Department of Basic Oncology, Oncology Institute, Hacettepe University, Sihhiye, Ankara, Turkey TR-06100Engin U. AkkayaDepartment of Chemistry, Middle East Technical University, Ankara, Turkey TR-06531, and Department of Basic Oncology, Oncology Institute, Hacettepe University, Sihhiye, Ankara, Turkey TR-06100
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Аннотация
[reaction: see text] A series of water-soluble green perylenediimide (PDI) dyes have been synthesized. On red light excitation, these dyes were shown to be efficient generators of singlet oxygen, and in cell culture media, they were shown to display significant light-induced cytotoxic effects on the human erythroleukemia cell line (K-562). It appears that highly versatile PDI dyes are likely to find new applications in photodynamic therapy.
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