Guanine, Adenine, and Hypoxanthine Production in UV‐Irradiated Formamide Solutions: Relaxation of the Requirements for Prebiotic Purine Nucleobase Formation
Hannah L. BarksSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400, USARagan BuckleyThese authors contributed equally to this workG. A. GrievesSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400 (USA),Ernesto Di MauroDipartimento di Genetica e Biologica Molecolare, Università La Sapienza, P. le Aldo Moro 5, 00185 Rome (Italy)Nicholas V. HudSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400 (USA),Thomas M. OrlandoSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332-0400 (USA),
2010en
ABI
Аннотация
Relaxed requirements: We demonstrate the formation of adenine, hypoxanthine, and guanine from heated (130 °C), UV-irradiated formamide solutions in the absence of an inorganic catalyst. Evidence is also provided that "classical" HCN pathways for purine nucleobase production are also active in heated and UV-irradiated formamide reactions. (Chemical Equation Presented) © 2010 Wiley-VCH Verlag GmbH& Co. KGaA.
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