Мақола

Neurologic and Neurobehavioral Sequelae in Children With Human Immunodeficiency Virus (HIV-1) Infection

Rajeshree GovenderDepartment of Paediatric Neurology, Red Cross Children’s Hospital, School of Child and Adolescent Health, University of Cape Town, South AfricaBrian EleyDepartment of Infectious Disease, Red Cross Children’s Hospital, School of Child and Adolescent Health, University of Cape Town, South AfricaKathleen WalkerDepartment of Paediatric Neurology, Red Cross Children’s Hospital, School of Child and Adolescent Health, University of Cape Town, South AfricaR. PetersenDepartment of Neurodevelopment, Red Cross Children’s Hospital, School of Child and Adolescent Health, University of Cape Town, South AfricaJo M. WilmshurstDepartment of Paediatric Neurology, Red Cross Children’s Hospital, School of Child and Adolescent Health, University of Cape Town, South Africa

2011en

ABI

Аннотация

The range and extent of neurologic and neurobehavioral complications of human immunodeficiency virus (HIV-1) infection in children are under-described. Seventy-eight children with HIV-1 infection (32 females) were assessed for neurologic complications. Forty-six children had abnormal neurology examinations. Thirty-three children had global pyramidal tract signs, 5 had a hemiparesis, 4 had peripheral neuropathy, 18 had visual impairment, and 5 had hearing impairment. Thirty-nine of 63 children over 1 year of age had neurobehavioral problems. Of 24 children with HIV encephalopathy, 74% had severe immunosuppression and 45% were not receiving antiretroviral therapy. Twelve children had prior opportunistic central nervous system infections, and 9 had epilepsy. Diverse neurologic and neurobehavioral deficits are common in children with HIV-1 infection. Children with severe immunosuppression, who were not receiving antiretroviral therapy, were growth impaired and less than 1 year of age, were at greatest risk for developing neurologic complications.

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Идентификаторлар

DOI: 10.1177/0883073811405203

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