Мақола

Antileishmanial potential of medicinal plant extracts from the North-West of Morocco

Abdelhakim BouyahyaBiology and Health Laboratory, Department of Biology, Faculty of Science, Abdelmalek Essaadi University, Tetouan, MoroccoAbdeslam Et-TouysLaboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Mohammed V University, Rabat, MoroccoNadia DakkaLaboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Mohammed V University, Rabat, MoroccoHajiba FellahNational Reference Laboratory of Leishmaniasis, National Institute of Health, Rabat, MoroccoJamal AbriniBiology and Health Laboratory, Department of Biology, Faculty of Science, Abdelmalek Essaadi University, Tetouan, MoroccoYoussef BakriLaboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Mohammed V University, Rabat, Morocco

2017en

ABI

Аннотация

The aim of this study is to evaluate the antileishmanial activity of selected medicinal plants from the North-West of Morocco. Plant extracts were prepared by maceration using methanol, ethanol, and n-hexane. The antileishmanial activity was evaluated against Leishmania major, Leishmania tropica, and Leishmania infantum using MTT (3-(4.5-dimethylthiazol-2yl)-2.5-diphenyltetrazolium bromide) assay. All plant extracts showed a reducing in cell promastigotes viability with variability depending on tested strains and type of extracts. The n-hexane extract showed the highest antileishmanial activity and L. infantum was the most sensitive parasite. The best growth inhibition was observed with Cistus crispus n-hexane extract against L. major (IC50 = 47.29 ± 2.25 μg/mL), Arbutus unedo n-hexane extract against L. infantum (IC50 = 64.05 ± 1.44 μg/mL) and Arbutus unedo n-hexane extract against L. tropica (IC50 = 79.57 ± 2.66 μg/mL). Considering these results, medicinal plants from the North-West of Morocco could constitute a promoter source for antileishmanial compounds.

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Идентификаторлар

DOI: 10.1016/j.bjbas.2017.06.003

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